I would say big yes. We're also considering to develop large scale eCommerce solution with Phalcon (if the project would be signed... :) )
Just take a look at other ready solutions like Magento2. That's hell.
And the question is not strictly bound to the Phalcon, but it's more a question of a decision whenever to develop such solution from scratch or not.
If you're sure you want that, Phalcon will be of a great help for sure.
Even if you develop views or not - we would go for a separate view component/app (Angular or so), so middleware programming is that what it is like in any core business.